Many years ago I started training myself to keep both eyes open when I shoot. My theory being (right or wrong) that it would give me a bit more peripheral vision and try to disipate some of the tunnel vision you can get in a deadly force encounter.
In my own personal AAR's of a situation I notice that I do still get some tunneling when I draw on someone but I "think" it's a little less than it was years ago. Both eyes open could be part of it but I suppose experience, also.
My PD issues us the Glock 22 .40 cal and prior to about 8 years ago, we carried the S&W 4506 which was a huge stainless steel .45 cal. Great gun but we were getting some smaller officers and they were having a hard time with the size of the 4506.
Plus, replacement parts were getting more expensive, didn't make that exact model anymore, harder to find training opportunities for armorers, etc.
I do personally find the Glock to be more "pointable".
I also carry an AR15 at work. I tend to switch between one eye or two eyes on that. Since we're not allowed telescopic sites (relfex is okay but it can't magnify) we only shoot out to 100 yards.
We shoot photo-type bad guy targets at full human size. I hit what I'm aiming at 100 yds whether I use one or two eyes, but I find it easier to concentrate using one eye at those ranges. Gets considerably easier as the range decreases.
At some of the closer range stuff (inside 15-20 feet I guess) we'll shoulder the rifle but shoot without sites.
Hock, why originally started to respond to this post was what you wrote about seeing the "ghostgun". If I don't focus on something with both eyes open, I'll get that sometimes. I generally focus on the front-site or occasionally on the target; either way gets rid of the ghost for me.